Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection
作者： Nadia Wauquier , Cindy Padilla , Pierre Becquart , Eric Leroy , Vincent Vieillard
DOI: 10.1007/S00251-010-0480-X
关键词:
摘要: Zaire ebolavirus (ZEBOV) infection rapidly outruns the host's immunity and leads to death within a week. Fatal cases have been associated with an aberrant innate, proinflammatory immune response followed by suppressed adaptive leading rapid depletion of peripheral NK cells lymphocytes. A critical role for has suggested but not elucidated. In this genetic study, we investigated association KIR genotype disease outcome comparing genotypes Gabonese control population, IgG+ contacts, survivors, fatalities ZEBOV infection. We showed that activating KIR2DS1 KIR2DS3 genes associate fatal in Ebola virus addition, study brings supplemental evidence favor specificity contact population. The fulminating could depend part on inherited gene repertoire. This supports key KIRs susceptibility infections.
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sci-hub.se 参考文章(28)
Sylvain Baize, Eric M. Leroy, M.-C. Georges-Courbot, Monique Capron, Joseph Lansoud-Soukate, Patrice Debré, Susan P. Fisher-Hoch, Joseph B. McCormick, Alain J. Georges, Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients. Nature Medicine. ,vol. 5, pp. 423- 426 ,(1999) , 10.1038/7422
Lisbeth A Guethlein, Clair M Gardiner, Nathalie W Cheng, Dolly Tyan, Neil Thomas Young, Peter Parham, Heather G Shilling, Genetic control of human NK cell repertoire ,(2001)
Caroline Besson, Sophie Roetynck, Fionnuala Williams, Laurent Orsi, Corinne Amiel, Catherine Lependeven, Guillemette Antoni, Olivier Hermine, Pauline Brice, Christophe Ferme, Patrice Carde, Danielle Canioni, Josette Brière, Martine Raphael, Jean-Claude Nicolas, Jacqueline Clavel, Derek Middleton, Eric Vivier, Laurent Abel, None, Association of killer cell immunoglobulin-like receptor genes with Hodgkin's lymphoma in a familial study. PLOS ONE. ,vol. 2, ,(2007) , 10.1371/JOURNAL.PONE.0000406
Christian Döhring, Marco Colonna, Human natural killer cell inhibitory receptors bind to HLA class I molecules. European Journal of Immunology. ,vol. 26, pp. 365- 369 ,(1996) , 10.1002/EJI.1830260215
Risa Miyashita, Naoyuki Tsuchiya, Toshio Yabe, Shigeto Kobayashi, Hiroshi Hashimoto, Shoichi Ozaki, Katsushi Tokunaga, Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis. Arthritis & Rheumatism. ,vol. 54, pp. 992- 997 ,(2006) , 10.1002/ART.21653
Nadia Wauquier, Pierre Becquart, Clélia Gasquet, Eric M. Leroy, Immunoglobulin G in Ebola Outbreak Survivors, Gabon Emerging Infectious Diseases. ,vol. 15, pp. 1136- 1137 ,(2009) , 10.3201/EID1507.090402
Thomas Hoenen, Allison Groseth, Darryl Falzarano, Heinz Feldmann, Ebola virus: unravelling pathogenesis to combat a deadly disease Trends in Molecular Medicine. ,vol. 12, pp. 206- 215 ,(2006) , 10.1016/J.MOLMED.2006.03.006
Pierre Becquart, Nadia Wauquier, Tanel Mahlakõiv, Dieudonné Nkoghe, Cindy Padilla, Marc Souris, Benjamin Ollomo, Jean-Paul Gonzalez, Xavier De Lamballerie, Mirdad Kazanji, Eric M. Leroy, High Prevalence of Both Humoral and Cellular Immunity to Zaire ebolavirus among Rural Populations in Gabon PLoS ONE. ,vol. 5, pp. e9126- ,(2010) , 10.1371/JOURNAL.PONE.0009126
S. BAIZE, E. M. LEROY, A. J. GEORGES, M.-C. GEORGES-COURBOT, M. CAPRON, I. BEDJABAGA, J. LANSOUD-SOUKATE, E. MAVOUNGOU, Inflammatory responses in Ebola virus-infected patients Clinical and Experimental Immunology. ,vol. 128, pp. 163- 168 ,(2002) , 10.1046/J.1365-2249.2002.01800.X
Wioleta Łuszczek, Maria Mańczak, Maria Cisło, Piotr Nockowski, Andrzej Wiśniewski, Monika Jasek, Piotr Kuśnierczyk, Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris. Human Immunology. ,vol. 65, pp. 758- 766 ,(2004) , 10.1016/J.HUMIMM.2004.05.008