Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis.

摘要: Objective Genetic background and infection have been implicated in the etiology of microscopic polyangiitis (MPA). Killer cell immunoglobulin-like receptors (KIRs) are a diverse family activating inhibitory expressed on natural killer (NK) cells T cells, genes which show extreme polymorphism. Some KIRs bind to HLA class I subgroups, genetic interactions between KIR their ligand shown be associated with several autoimmune viral diseases. In this study, we examined possible associations presence or absence loci predisposition MPA. Methods The 14 was determined 57 myeloperoxidase antineutrophil cytoplasmic antibody–positive Japanese subjects (43 patients MPA 239 healthy controls). Results The carrier frequency KIR2DS3 significantly decreased among compared controls (4.7% versus 16.7%; P = 0.038, odds ratio [OR] 0.24, 95% confidence interval [95% CI] 0.06–0.94). When were analyzed combination ligands, proportion individuals carrying KIR3DL1 HLA–Bw4 but not receptor KIR3DS1, presumed most all KIR3DS1/3DL1/HLA–B combinations, increased group control (46.5% 27.0%; 0.014, OR 2.35, CI 1.18–4.70). Furthermore, when classified according KIR3DL1/3DS1/HLA–B KIR2DL1/ HLA–C an increasing trend toward susceptibility observed as combinations became more inhibitory. Conclusion The activation potential NK and/or KIR/HLA genotypes may predispose MPA, possibly through insufficient resistance against infections.