Association of killer cell immunoglobulin-like receptor genotypes with susceptibility to endometriosis.
作者： Jo Kitawaki , Bing Xu , Hiroaki Ishihara , Michiaki Fukui , Goji Hasegawa
DOI: 10.1111/J.1600-0897.2007.00533.X
关键词:
摘要: Problem Endometriosis is an immune-related chronic inflammatory disease with a polygenic predisposition. The aim of this study was to investigate whether polymorphisms in killer cell immunoglobulin-like receptors (KIRs) responsible, part, for genetic susceptibility endometriosis. Method study KIRs genotype determined 186 patients endometriosis and 165 control women using polymerase chain reaction sequence-specific primers. Results frequency KIR3DS1 significantly decreased compared controls (32%versus 44%, P = 0.028). KIR data were analyzed model comprised three large groups, which gradient activation/inhibitory potential derived from the combination human leukocyte antigen (HLA) ligand genes taken into account. inhibitory KIRs/HLA-class I genotypes higher than (χ2 = 6.010, 2 df, P = 0.0496). Conclusion Our results suggest that polymorphism may be associated endometriosis.
sci-hub.se 参考文章(26)
Trevor J. Wilson, Paul J. Hertzog, Dianne Angus, Leah Munnery, E. Carl Wood, Ismail Kola, Decreased natural killer cell activity in endometriosis patients: relationship to disease pathogenesis**Supported by Monash IVF, Richmond, Victoria, Australia. Fertility and Sterility. ,vol. 62, pp. 1086- 1088 ,(1994) , 10.1016/S0015-0282(16)57082-4
Didier J. Oosterlynck, Freddy J. Cornillie, Mark Waer, Michel Vandeputte, Philippe R. Koninckx, Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertility and Sterility. ,vol. 56, pp. 45- 51 ,(1991) , 10.1016/S0015-0282(16)54414-8
Joe Leigh Simpson, Sherman Elias, L.Russell Malinak, Veasy C. Buttram, Heritable aspects of endometriosis American Journal of Obstetrics and Gynecology. ,vol. 137, pp. 327- 331 ,(1980) , 10.1016/0002-9378(80)90917-5
Lewis L. Lanier, Brian C. Corliss, Jun Wu, Clement Leong, Joseph H. Phillips, Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells Nature. ,vol. 391, pp. 703- 707 ,(1998) , 10.1038/35642
Charalambos Siristatidis, Christos Nissotakis, Charalambos Chrelias, Helen Iacovidou, Emmanuel Salamalekis, Immunological factors and their role in the genesis and development of endometriosis ARTICLE HAS BEEN RETRACTED Journal of Obstetrics and Gynaecology Research. ,vol. 32, pp. 162- 170 ,(2006) , 10.1111/J.1447-0756.2006.00373.X
M Cella, A Longo, G B Ferrara, J L Strominger, M Colonna, NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80. Journal of Experimental Medicine. ,vol. 180, pp. 1235- 1242 ,(1994) , 10.1084/JEM.180.4.1235
Mette H. Moen, Per Magnus, The familial risk of endometriosis Acta Obstetricia et Gynecologica Scandinavica. ,vol. 72, pp. 560- 564 ,(1993) , 10.3109/00016349309058164
A. P. Williams, Hanging in the balance: KIR and their role in disease Molecular Interventions. ,vol. 5, pp. 226- 240 ,(2005) , 10.1124/MI.5.4.6
Risa Miyashita, Naoyuki Tsuchiya, Toshio Yabe, Shigeto Kobayashi, Hiroshi Hashimoto, Shoichi Ozaki, Katsushi Tokunaga, Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis. Arthritis & Rheumatism. ,vol. 54, pp. 992- 997 ,(2006) , 10.1002/ART.21653
A. Selvakumar, U. Staffens, N. Palanisamy, R. S. K. Chaganti, B. Dupont, Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103. Tissue Antigens. ,vol. 49, pp. 564- 573 ,(1997) , 10.1111/J.1399-0039.1997.TB02803.X