The Role of the Thymus in Development of Necrotizing Arteritis in Transgenic Rats Carrying the env-pX Gene of Human T-Cell Leukemia Virus Type-I
作者： Kazunori Fugo , Akihiro Ishizu , Hitoshi Ikeda , Hiroko Hayase , Toshiaki Sugaya
DOI: 10.1016/S0002-9440(10)64234-4
关键词:
摘要: Necrotizing arteritis mimicking polyarteritis nodosa occurred in transgenic rats carrying the env-pX gene of human T-cell leukemia virus type I. To investigate pathogenesis necrotizing these (env-pX rats), adoptive transfers spleen cells and bone marrow were done from before they developed to nontransgenic rats. lethally irradiated reconstituted by cells, thus indicating that transgene affected vessels may not be essential for development arteritis. In contrast, was induced recipients which suggested T derived thymus play a role clarify if process differentiation is crucial develop arteritis, reciprocal exchange frameworks between with an framework, whereas suppressed framework replaced one. This collective evidence shows directly associated
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