Biodegradable Smart Nanogels: A New Platform for Targeting Drug Delivery and Biomedical Diagnostics

作者: Hai-Qiu Wu , Chang-Chun Wang

DOI: 10.1021/ACS.LANGMUIR.6B00842

关键词:

摘要: Nanogels (or nanohydrogels) have been extensively investigated as one of the most promising nanoparticulate biomedical platforms owing to their advantageous properties that combine characteristics hydrogel systems with nanoparticles. Among them, smart nanogels ability respond external stimuli, such pH, redox, temperature, enzymes, light, magnetic field and so forth, are attractive in area drug delivery. Besides, numerous multifunctionalized high sensitivity specificity were designed for diagnostic applications. In this feature article, we reviewed discussed recent progress biodegradable nanocarriers anticancer drugs agents cancer.

参考文章(70)
Sha Jin, Dian Li, Peng Yang, Jia Guo, Jennifer Q. Lu, Changchun Wang, Redox/pH stimuli-responsive biodegradable PEGylated P(MAA/BACy) nanohydrogels for controlled releasing of anticancer drugs Colloids and Surfaces A: Physicochemical and Engineering Aspects. ,vol. 484, pp. 47- 55 ,(2015) , 10.1016/J.COLSURFA.2015.07.041
Sha Jin, Jiaxun Wan, Lizheng Meng, Xiaoxing Huang, Jia Guo, Li Liu, Changchun Wang, Biodegradation and Toxicity of Protease/Redox/pH Stimuli-Responsive PEGlated PMAA Nanohydrogels for Targeting Drug delivery. ACS Applied Materials & Interfaces. ,vol. 7, pp. 19843- 19852 ,(2015) , 10.1021/ACSAMI.5B05984
Hui Wang, Jing Di, Yubing Sun, Jianping Fu, Zengyan Wei, Hiroshi Matsui, Alejandra del C. Alonso, Shuiqin Zhou, Biocompatible PEG-Chitosan@Carbon Dots Hybrid Nanogels for Two-Photon Fluorescence Imaging, Near-Infrared Light/pH Dual-Responsive Drug Carrier, and Synergistic Therapy Advanced Functional Materials. ,vol. 25, pp. 5537- 5547 ,(2015) , 10.1002/ADFM.201501524
Zehedina Khatun, Md Nurunnabi, Md Nafiujjaman, Gerald R. Reeck, Haseeb A. Khan, Kwang Jae Cho, Yong-kyu Lee, A hyaluronic acid nanogel for photo–chemo theranostics of lung cancer with simultaneous light-responsive controlled release of doxorubicin Nanoscale. ,vol. 7, pp. 10680- 10689 ,(2015) , 10.1039/C5NR01075F
Yang Wang, Jin Zheng, Yefei Tian, Wuli Yang, Acid degradable poly(vinylcaprolactam)-based nanogels with ketal linkages for drug delivery Journal of Materials Chemistry B. ,vol. 3, pp. 5824- 5832 ,(2015) , 10.1039/C5TB00703H
Lidi Chen, Yanan Xue, Xiaoyang Xia, Meifang Song, Juan Huang, Han Zhang, Bo Yu, Sihui Long, Yanping Liu, Lei Liu, Shiwen Huang, Faquan Yu, A redox stimuli-responsive superparamagnetic nanogel with chemically anchored DOX for enhanced anticancer efficacy and low systemic adverse effects Journal of Materials Chemistry B. ,vol. 3, pp. 8949- 8962 ,(2015) , 10.1039/C5TB01851J
K. Madhusudana Rao, K.S.V. Krishna Rao, G. Ramanjaneyulu, Chang-Sik Ha, Curcumin encapsulated pH sensitive gelatin based interpenetrating polymeric network nanogels for anti cancer drug delivery. International Journal of Pharmaceutics. ,vol. 478, pp. 788- 795 ,(2015) , 10.1016/J.IJPHARM.2014.12.001
Xin Wang, Xikuang Yao, Yajun Zhang, Wei Wu, Xiqun Jiang, Chenchen Yang, Hyaluronic acid nanogels with enzyme-sensitive cross-linking group for drug delivery Journal of Controlled Release. ,vol. 205, pp. 206- 217 ,(2015) , 10.1016/J.JCONREL.2015.02.008
Muxun Zhao, Biliang Hu, Zhen Gu, Kye-Il Joo, Pin Wang, Yi Tang, Degradable polymeric nanocapsule for efficient intracellular delivery of a high molecular weight tumor-selective protein complex Nano Today. ,vol. 8, pp. 11- 20 ,(2013) , 10.1016/J.NANTOD.2012.12.003