Hypothalamic-pituitary-testicular function in prepubertal children with chronic liver disease.

摘要: Adult patients with chronic liver disease (CLD) show clinical and biochemical signs of hypogonadism estrogenization. However, no information is available on hypothalamo-pituitary-testicular function in prepubertal or early pubertal children CLD. Eighteen CLD, aged 5.8+/-5.5 years (mean +/- SD; range 0.32-12.8), were studied. Most them had moderate abnormality. Height was slightly decreased (SDS: -1.44-/+1.88) but weight for height adequate. Serum gonadotropins evaluated as a age. In the age group younger than 1 year (n = 7), serum LH elevated (4.88+/-6.22 IU/l) when compared 39 control (1.2+/-1.65), while FSH normal. this young group, testosterone normal, estradiol significantly increased (24.1+/-19.7 pg/ml) (6.5+/-3.54). contrast, older 2 years, difference between CLD controls observed, either sex hormones. Taking 18 together, SHBG (113.7+/-51 nmol/l; mean SD) higher normal (76+/-38 nmol/l, n 91, p ng/ml) found subgroup 11 By eight an inadequate decrease after androgen stimulation. conclusion, we observed that during first life, period which includes postnatal activation axis, there elevation suggests existence deficiency Leydig cell function. This disorder longer children. Similar to reports adults, have levels. Furthermore, lack bioavailable increase age, probably modulated by GH, some degree hepatic GH resistance