Protective role of Urtica dioica L. (Urticaceae) extract on hepatocytes morphometric changes in STZ diabetic Wistar rats.

作者: Mohammad Jafar Golalipour , Soraya Ghafari , Mohammad Afshar , None

DOI: 10.4318/TJG.2010.0098

关键词:

摘要: BACKGROUND/AIMS The present investigation was carried out to evaluate the protective effect of hydroalcoholic extract Urtica dioica leaves on quantitative morphometric changes in liver streptozotocin-induced diabetic rats. METHODS Thirty male Wistar rats were divided into control (G1), (G2), + (G3) groups. group received only sham injections intraperitoneal saline; saline for 5 days followed by streptozotocin (80 mg/kg) 6th day; and 100 mg/kg (7) injection day. After five weeks, animals sacrificed whole livers removed. Liver specimens used analysis after hematoxylin eosin staining. All data statistically analyzed one-way ANOVA expressed as mean with standard error means. RESULTS In G3 (diabetic diocia) group, surface area hepatocytes periportal zone (Z1) greater than G2 (diabetic) G1 (control) groups, but this difference not significant. No alteration observed perivenous (Z3) compared (G2) group. nuclear higher Z1 lower Z3 that diameter hepatocyte nuclei (G1) groups both Z3. CONCLUSIONS This study revealed administration before induction has a alterations zones lobule

参考文章(32)
John D. Bancroft, Marilyn Gamble, Theory and Practice of Histological Techniques ,(1990)
Rana Pratap Singh, Bandhuvula Padmavathi, Araga Ramesha Rao, Modulatory influence of Adhatoda vesica (Justicia adhatoda) leaf extract on the enzymes of xenobiotic metabolism, antioxidant status and lipid peroxidation in mice. Molecular and Cellular Biochemistry. ,vol. 213, pp. 99- 109 ,(2000) , 10.1023/A:1007182913931
N Yildizogluari, Y Ozturk, Vecdi Altan, Effects of experimental diabetes and insulin on smooth muscle functions. Pharmacological Reviews. ,vol. 48, pp. 69- 112 ,(1996)
Norbert R. Katz, Metabolic heterogeneity of hepatocytes across the liver acinus. Journal of Nutrition. ,vol. 122, pp. 843- 849 ,(1992) , 10.1093/JN/122.SUPPL_3.843
Costantine F. Daher, Karmen G. Baroody, George M. Baroody, Effect of Urtica dioica extract intake upon blood lipid profile in the rats Fitoterapia. ,vol. 77, pp. 183- 188 ,(2006) , 10.1016/J.FITOTE.2006.01.010
Kazuo Kanai, Jun Watanabe, Satoshi Fujimoto, Shinsuke Kanamura, Quantitative analysis of smooth endoplasmic reticulum proliferation in periportal, midzonal and perivenular hepatocytes of mice after administration of phenobarbital Experimental and Toxicologic Pathology. ,vol. 45, pp. 199- 203 ,(1993) , 10.1016/S0940-2993(11)80387-8
Abdelkhaleq Legssyer, Abderrahim Ziyyat, Hassane Mekhfi, Mohamed Bnouham, Abdelhafid Tahri, Mohamed Serhrouchni, Jacqueline Hoerter, Rodolphe Fischmeister, Cardiovascular effects of Urtica dioica L. in isolated rat heart and aorta Phytotherapy Research. ,vol. 16, pp. 503- 507 ,(2002) , 10.1002/PTR.1087
Yishai Levy, Haya Zaltzberg, Ami Ben-Amotz, Yoram Kanter, Michael Aviram, β-Carotene affects antioxidant status in non-insulin-dependent diabetes mellitus Pathophysiology. ,vol. 6, pp. 157- 161 ,(1999) , 10.1016/S0928-4680(99)00013-9