Heterogeneity of presynaptic serotonin receptors on sympathetic neurones in blood vessels.

摘要: Presynaptic serotonin (5-HT) receptors on the postganglionic sympathetic nerves, which mediate inhibition of noradrenaline release in blood vessels various species and interact with presynaptic α2-autoreceptors, are heterogeneous. In rat vena cava, they 5-HT1B subtype, pig coronary artery belong to a novel, so far unknown class 5-HT receptors, human saphenous vein could be classified as 5-HT1D. These results point marked differences need carry out experiments vascular preparations. may involved mechanism action new antimigraine drug sumatriptan.