Mechanisms of Ischemic Preconditioning in Rat Myocardium

摘要: Background Adenosine has been proposed as one mediator for the preconditioning effect in myocardium of some animals, but recent investigations have shown that this may not be mechanism rat heart, although itself is clearly demonstrable. The cellular energy state to better preconditioned hearts, and role ATP consumption discussed. inhibition mitochondrial F1Fo-ATPase a preservation hearts remains controversial. Methods Results Three-minute global ischemia followed by 9 minutes reperfusion was used precondition Langendorff-perfused control were perfused under normoxic conditions same time. duration sustained both groups 21 minutes, after which reperfused 15 evaluate their mechanical metabolic recovery. Separate experiments performed tissue metabolite determinations, mit...