Teratogenic effects of noise in mice

摘要: Abstract This study was undertaken to assess the hazardous effects of noise on embryonic development. The experiment composed two parts; one observation effect due alone, and other combined known teratogens. ICR mice were exposed a wide octave-band at 100 dB(C) for 6 hours day in three ways: first group continuous only 7 pregnancy (group “N”), second an intermittent (15 min ON/15 OFF) “IN”), third daily during days 7–12 “RN”). Cadmium sulfate or trypan blue applied as teratogen, administered intraperitoneously pregnancy. On 18 pregnancy, sacrificed developmental status external malformations their fetuses examined. Each type exposure did not significantly induce embryolethality fetal growth retardation. However, teratogenicity observed groups “N” “IN”. Combined teratogen show clear-cut interactions.