New Strategy of Treatment for Esophageal Squamous Cell Carcinoma Using Immunotoxin Which Reacts to Epidermal Growth Factor Receptor
作者： Soji Ozawa , Masakazu Ueda , Norifumi Hirota , Nobutoshi Ando , Masaki Kitajima
DOI: 10.1007/978-4-431-68246-2_66
关键词:
摘要: Squamous cell carcinoma is by far the most common neoplasm of esophagus and survival rate its patients generally low [1]. To treat this cancer more effectively, it necessary to develop a strategy targeted therapy. Most squamous cells hyperproduce epidermal growth factor (EGF) receptor [2, 3], EGF in turn promotes receptor-hyperproducing vivo [4]. Moreover, an elevated level significant prognostic for with esophageal [5]. Therefore, since system play important role cancer, ideal surface object We synthesized immunotoxin consisting murine monoclonal antibody (B4G7) against human gelonin, 60s ribosome-inactivating protein. studied cytotoxic effects on tumors, investigated possibility as new treatment carcinoma.
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