Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas.
作者： Nicolai Aagaard Schultz , Anne Roslind , Ib J. Christensen , Thomas Horn , Estrid Høgdall
DOI: 10.1097/MPA.0B013E31823CD9DF
关键词:
摘要: OBJECTIVES The frequencies and prognostic role of KRAS BRAF mutations in patients operated on for pancreatic ductal adenocarcinomas (PDACs) ampullary (A-ACs) are scantily studied. METHODS were analyzed formalin-fixed, paraffin-embedded tumor samples from primarily chemotherapy-naive with radical intentions PDAC (n = 170) A-AC 107). RESULTS Eighty percent had (codon 12 mutations: 74%) 67% 54%). less common, 16% 12% A-AC, no V600E found. Fourteen 7% both BRAF. Multivariate analysis, including status, stage, American Society Anesthesiologists physical status classification system score, demonstrated that associated short recurrence-free survival (RFS) (hazard ratio, 2.45; 95% confidence interval, 1.19-5.06; P 0.015) overall (OS) (1.93, 1.12-3.31; 0.018). not RFS OS. CONCLUSIONS high A-AC. poor prognosis but PDAC.
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