Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions

摘要: Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or direct contact with blood tissues viremic patients animals. It causes a severe disease fatality up 30%. The current knowledge about the vector-host-CCHFV interactions very limited due high-level containment required for CCHFV studies. Among ticks, Hyalomma spp. are considered most competent vectors. evades tick immune response, and following its replication in lining tick's midgut, it disseminated hemolymph salivary glands reproductive organs. introduction gland secretions into host cells major route via which enters host. Following an initial amplification at site inoculation, spread target Apoptosis induced both intrinsic extrinsic pathways. Genetic factors status may affect release cytokines play role progression outcome. expected that use new technology metabolomics, transcriptomics proteomics will lead improved understanding CCHFV-host identify potential targets blocking transmission.