摘要: The first identified protein kinase exhibiting direct activation by a Ras-related GTPase was brain p21(Cdc42/Rac) activated designated p65PAK(Manser et al 1994).The kinase(s) were originally in [γ32P]GTPCdc42 and [γ32P]GTP-Rac1 overlays of SDS-polyacrylamide gel fractionated proteins(Manser al. 1993). presence similar sized target proteins all tissues suggested that these serine/threonine kinases ubiquitous. In binding the active GTP-forms Cdc42 Racl, α-and γ-PAKs also decrease intrinsic GTP hydrolysis block action activating (GAPs). This therefore favours signalling to PAK. However, βPAK may be released after allowing for amplification signal or initiation other p21 actions(Manser 1995, Manser 1994).
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