Necrotic Bilateral Buttocks Ulcerations Occurring After Multiple Intramuscular Iron Dextran Injections

摘要: To the Editor.— Usual adverse effects from intramuscular iron dextran injections include skin pigmentation and transient pain localized at injection site. Muscle necrosis tissue fibrosis have been demonstrated experimentally with multiple high-dose of in some animals, 1 but muscle ulceration overlying has not reported previously man. Report a Case.— A 72-year-old man ten-year history rheumatoid arthritis presented August 1986 for evaluation hip ulcers bilaterally. The ulcerations occurred where he had received treatment an undefined anemia. He was given approximately 350 over five years, alternating between hips. Assuming 2-mL 50 mg/mL (1.2 mg/kg) Imferon, cumulative dose estimated to be 37 000 mg (435 mg/kg). Since his initial visit clinic 1984, any injections.