Risk of Amyotrophic Lateral Sclerosis and Exposure to Particulate Matter from Vehicular Traffic: A Case-Control Study.

摘要: (1) Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with still unknown etiology. Some occupational and environmental risk factors have been suggested, including long-term air pollutant exposure. We carried out pilot case-control study in order to evaluate ALS due particulate matter diameter of ≤10 µm (PM10) as proxy vehicular traffic (2) Methods: recruited patients controls referred the Modena Neurology Care Center between 1994 2015. Using geographical information system, we modeled PM10 concentrations emissions at geocoded residence address date case diagnosis. computed odds ratio (OR) 95% confidence interval (CI) according increasing exposure, using an unconditional logistic regression model adjusted for age sex. (3) Results: For 132 participants (52 cases 80 controls), average annual median maximum were 5.2 38.6 µg/m3, respectively. fixed cutpoints 5, 10, 20 levels, compared exposure <5 found no excess 5-10 µg/m3 (OR 0.87, CI 0.39-1.96), 10-20 (0.94, 0.24-3.70), ≥20 (0.87, 0.05-15.01). Based on concentrations, statistically unstable subjects exposed 4.27, 0.69-26.51) those <10 µg/m3. However, decreased 20-50 1.49, 0.39-5.75) ≥50 (1.16, 0.28-4.82). tertiles showed similar null association, while comparison highest three lowest quartiles lumped together little evidence 1.13, 0.50-2.55). After restricting analysis stable residence, substantially results. (4) Conclusions: In this study, limited increased high concentration, though statistical imprecision estimates, small sample size, particularly some categories, our capacity detect increases risk, further larger studies are needed assess relation.