Incidence of amyotrophic lateral sclerosis in the province of Novara, Italy, and possible role of environmental pollution.

摘要: AbstractObjective and methods: Based on nationwide death certificates, a cluster of amyotrophic lateral sclerosis (ALS) has been reported in the area Briga (Novara province, northern Italy), known for its severe environmental contamination. We further investigated this finding, by following up with collection recent incidence ALS data 2002–2012 Novara also to assess possible long-term effects pollution that area. Results: In whole province we identified 106 cases, which 35 were from Incidence rates 3.98, 5.14 2.97 total population, males females, respectively, compared where they 4.65, 4.27 4.98, respectively. The ratio observed-to-expected cases area, using rest as reference, was 1.17 (95% CI 0.81–1.62), value 0.83 0.47–1.37) 1.68 1.03–2.60) females. Concl...