Magnetic fields exposure from high-voltage power lines and risk of amyotrophic lateral sclerosis in two Italian populations.

摘要: The aetiology of amyotrophic lateral sclerosis (ALS), a rare and extremely severe neurodegenerative disease, has been associated with magnetic fields exposure. However, evidence for such relation in the general population is weak, although previous null results might also be due to exposure misclassification, or relationship exist only selected subgroups. To test hypothesis we carried out population-based case-control study two Northern Southern Italy regions, including 703 ALS cases newly diagnosed from 1998 2011 2737 controls randomly residents provinces. Overall, found that residence near high-voltage power lines, within corridors yielding ≥0.1 μT, was not an excess disease risk, nor did identify dose-response after splitting exposed corridor according 0.1, 0.2 0.4 μT cut-points These were confirmed taking into account age at onset, period diagnosis, sex, geographical area, length despite residual possibility unmeasured confounding small susceptible subgroups identified our study, these appear confirm lines occurring increased risk.