摘要: In 1997, during an outbreak in chickens Hong Kong the avian H5N1 influenza virus crossed species barrier and infected 18 people, of which 6 cases were fatal. The also wild birds continued to circulate mutate geese ducks southeastern China. Since this occurrence, new antigenic variants that are highly pathogenic for humans as well wild, domestic, exotic waterfowl continue appear Kong. This is spreading across Asia, encroaching upon Europe other continents. Wild now considered main reservoir virus. Humans become with usually via close contact or a contaminated environment. very low transmissibility prevented further person-to-person dissemination spite complete absence immunity human population viruses. Viruses subtype characterized by exceptionally high pathogenicity humans. cause viral virulence not known so far; however, several factors considered. unprecedented capability viruses kill intensifies concern about its pandemic potential catastrophic consequences. effectiveness existing antivirals vaccines reviewed.
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