Influenza A Vaccine Based on the Extracellular Domain of M2: Weak Protection Mediated via Antibody-Dependent NK Cell Activity

作者: Andrea Jegerlehner , Nicole Schmitz , Tazio Storni , Martin F. Bachmann

DOI: 10.4049/JIMMUNOL.172.9.5598

关键词:

摘要: … by Abs, a very important feature of a successful preventive vaccine. However, these Abs neither … The absence of neutralizing Abs results in much weaker protection than that achieved by …

参考文章(43)
R. J. Sugrue, G. Bahadur, M. C. Zambon, M. Hall-Smith, A. R. Douglas, A. J. Hay, Specific structural alteration of the influenza haemagglutinin by amantadine. The EMBO Journal. ,vol. 9, pp. 3469- 3476 ,(1990) , 10.1002/J.1460-2075.1990.TB07555.X
W. Gerhard, The role of the antibody response in influenza virus infection. Current Topics in Microbiology and Immunology. ,vol. 260, pp. 171- 190 ,(2001) , 10.1007/978-3-662-05783-4_9
W. R. Dowdle, J. C. Downie, W. G. Laver, Inhibition of virus release by antibodies to surface antigens of influenza viruses. Journal of Virology. ,vol. 13, pp. 269- 275 ,(1974) , 10.1128/JVI.13.2.269-275.1974
I D Bernstein, C C Badger, E Y Denkers, J A Ledbetter, Influence of antibody isotype on passive serotherapy of lymphoma. Journal of Immunology. ,vol. 135, pp. 2183- 2186 ,(1985)
A.J. Hay, A.J. Wolstenholme, J.J. Skehel, M.H. Smith, The molecular basis of the specific anti-influenza action of amantadine. The EMBO Journal. ,vol. 4, pp. 3021- 3024 ,(1985) , 10.1002/J.1460-2075.1985.TB04038.X
Sabine Neirynck, Tom Deroo, Xavier Saelens, Peter Vanlandschoot, Willy Min Jou, Walter Fiers, A universal influenza A vaccine based on the extracellular domain of the M2 protein. Nature Medicine. ,vol. 5, pp. 1157- 1163 ,(1999) , 10.1038/13484
M Ohuchi, A Cramer, M Vey, R Ohuchi, W Garten, H D Klenk, Rescue of vector-expressed fowl plague virus hemagglutinin in biologically active form by acidotropic agents and coexpressed M2 protein. Journal of Virology. ,vol. 68, pp. 920- 926 ,(1994) , 10.1128/JVI.68.2.920-926.1994
J J Treanor, E L Tierney, S L Zebedee, R A Lamb, B R Murphy, Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice. Journal of Virology. ,vol. 64, pp. 1375- 1377 ,(1990) , 10.1128/JVI.64.3.1375-1377.1990
Julie Jameson, John Cruz, Francis A. Ennis, Human Cytotoxic T-Lymphocyte Repertoire to Influenza A Viruses Journal of Virology. ,vol. 72, pp. 8682- 8689 ,(1998) , 10.1128/JVI.72.11.8682-8689.1998