Left atrial structure and function and clinical outcomes in the general population

摘要: Aims Left atrial (LA) structural and functional abnormalities may be subclinical phenotypes, which identify individuals at increased risk of adverse outcomes. Methods results Maximum LA volume (LAmax) emptying fraction (LAEF) were measured via cardiac magnetic resonance imaging in 1802 participants the Dallas Heart Study. The associations LAEF LAmax indexed to body surface area (LAmax/BSA) with traditional factors, natriuretic peptide levels, left ventricular (LV) structure [end-diastolic (EDV) concentricity0.67 (mass/EDV0.67)] function (ejection fraction) assessed using linear regression analysis. incremental prognostic value LAmax/BSA beyond LV ejection fraction, mass was Cox proportional-hazards model. Both increasing decreasing associated hypertension levels ( P < 0.05 for all). In multivariable analysis, most strongly end-diastolic volume/BSA, while concentricity0.67. During a median follow-up period 8.1 years, there 81 total deaths. Decreasing [hazard ratio (HR) per 1 standard deviation (SD) (8.0%): 1.56 (1.32–1.87)] but not [HR SD (8.6 mL/m2): 1.14 (0.97–1.34)] independently mortality. Furthermore, addition model adjusting Framingham score, diabetes, race, mass, improved c -statistic -statistics: 0.78 vs. 0.77; 0.05, respectively), whereas did 0.76, = 0.20). Conclusion general population, both are important phenotypes is superior LAmax/BSA.