MicroRNA-34a suppresses invasion and metastatic in esophageal squamous cell carcinoma by regulating CD44.
作者： Jianhui Zuo , Kechao Zhu , Yunhai Wang , Zaicheng Yu
DOI: 10.1007/S11010-017-3218-3
关键词:
摘要: In human esophageal squamous cell carcinoma (ESCC), miR-34a was downregulated and could inhibit in vitro proliferation migration. However, the underlying mechanism not clear yet. The expression levels of mRNA protein were detected by quantitative real-time PCR or western blotting, respectively. MiR-34a knocked down overexpressed transfected into ESCC lines ECA109 TE-13, Cell migration wound healing assays used to examine effect on invasion vitro. Animal models role metastasis vivo. Luciferase assay carried out validate potential target miR-34a. CD44 upregulated tissues lines. linear regression analysis showed that negatively correlated with level interacted a putative binding site 3′UTR. found regulate CD44. experiment overexpression inhibited migration; whereas knockdown reversed results. also esophagus tumor growth vivo; Finally, we effects MiRNA-34a suppresses metastatic regulating
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