Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion.

摘要: Inflammation in the middle ear mucosa, caused usually by bacterial and viral pathogens, is primary event predisposing development of otitis media with effusion (OME). Numerous inflammatory mediators have been identified OME. However, cytokines play a central role as initiators, regulators inflammation subsequent molecular-pathological processes tissues, leading to histopathological changes cavity pathogenesis In this article, we aim present an overview current research developments pro-inflammatory cytokine involvement aetiology effusion.