CoWO4-x-based nanoplatform for multimode imaging and enhanced photothermal/photodynamic therapy

摘要: Abstract Although phototherapy has received widespread attention in recent years due to its high efficiency, low invasiveness, and minor side effects, there are still few studies on the relationship between immunotherapy. Therefore, non-stoichiometric CoWO4-x nanoparticles (NPs) were strategically designed prepared, as these can simultaneously generate hyperthermia reactive oxygen species (ROS) under near-infrared laser irradiation, illustrating that they be used realize photothermal therapy (PTT) photodynamic (PDT) tumors. NPs not only have strong absorption, outstanding biocompatibility, excellent stability but also photoacoustic (PA) Computer Tomography (CT) contrast agents for working with In particular, relationships phototherapy, immunogenic cell death (ICD) immunoresistance here discussed depth, enhanced was achieved first time by injecting etoposide ML385, which two typical inhibitors HSP60 NRF2, respectively. Furthermore, biocompatibility of materials vivo demonstrated through a variety experiments, changes mouse body weight, histological analyses. Our work highlights great potentials kind multifunctional therapeutic agent implementing breast cancer reducing NRF2 toward PTT PDT.