Thyroid hormone and hemodynamic regulation of beta-myosin heavy chain promoter in the heart.

作者: K Ojamaa , J D Klemperer , S S MacGilvray , I Klein , A Samarel

DOI: 10.1210/ENDO.137.3.8603588

关键词:

摘要: Thyroid hormone exerts marked effects on cardiovascular function. Expression of cardiac alpha- and beta-myosin heavy chain (MHC) isoforms can be altered in response to thyroid as well by hemodynamic changes imposed the heart. The molecular mechanisms that mediate these are not completely known. We studied contractile responsiveness betaMHC promoter both cultured myocytes vivo direct DNA transfer. Using transient transfection neonatal rat cardiomyocytes, activities recombinant reporter plasmids containing 5'-flanking sequences terminating at positions -2250, -1145, -670, -354 were decreased significantly cultures L-T3 (50 nM). Similar deletion analysis showed regions within -2250 -151 bp contractility responsive; however, position -126 attenuated this response. In activity, determined injecting plasmid into th...

参考文章(27)
WILLIAM W. CHIN, FRANCES E. CARR, JOAN BURNSIDE, DOUGLAS S. DARLING, Thyroid Hormone Regulation of Thyrotropin Gene Expression Recent Progress in Hormone Research. ,vol. 48, pp. 393- 414 ,(1993) , 10.1016/B978-0-12-571148-7.50018-X
G. W. Dorn, J. Robbins, N. Ball, R. A. Walsh, MYOSIN HEAVY CHAIN REGULATION AND MYOCYTE CONTRACTILE DEPRESSION AFTER LV HYPERTROPHY IN AORTIC-BANDED MICE American Journal of Physiology-heart and Circulatory Physiology. ,vol. 267, ,(1994) , 10.1152/AJPHEART.1994.267.1.H400
D.S. Darling, R.L. Carter, P.M. Yen, J.M. Welborn, W.W. Chin, P.K. Umeda, Different dimerization activities of alpha and beta thyroid hormone receptor isoforms. Journal of Biological Chemistry. ,vol. 268, pp. 10221- 10227 ,(1993) , 10.1016/S0021-9258(18)82193-7
P.M. Yen, D.S. Darling, R.L. Carter, M Forgione, P.K. Umeda, W.W. Chin, Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers. Journal of Biological Chemistry. ,vol. 267, pp. 3565- 3568 ,(1992) , 10.1016/S0021-9258(19)50559-2
M K Song, B Dozin, D Grieco, J E Rall, V M Nikodem, Transcriptional activation and stabilization of malic enzyme mRNA precursor by thyroid hormone. Journal of Biological Chemistry. ,vol. 263, pp. 17970- 17974 ,(1988) , 10.1016/S0021-9258(19)81310-8
J Sadoshima, L Jahn, T Takahashi, T.J. Kulik, S Izumo, Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. Journal of Biological Chemistry. ,vol. 267, pp. 10551- 10560 ,(1992) , 10.1016/S0021-9258(19)50052-7
A. Subramaniam, J. Gulick, J. Neumann, S. Knotts, J. Robbins, Transgenic analysis of the thyroid-responsive elements in the alpha-cardiac myosin heavy chain gene promoter. Journal of Biological Chemistry. ,vol. 268, pp. 4331- 4336 ,(1993) , 10.1016/S0021-9258(18)53614-0
L L Cribbs, N Shimizu, C E Yockey, J E Levin, S Jakovcic, R Zak, P K Umeda, Muscle-specific regulation of a transfected rabbit myosin heavy chain beta gene promoter. Journal of Biological Chemistry. ,vol. 264, pp. 10672- 10678 ,(1989) , 10.1016/S0021-9258(18)81675-1
H. Rindt, J. Gulick, S. Knotts, J. Neumann, J. Robbins, In vivo analysis of the murine beta-myosin heavy chain gene promoter. Journal of Biological Chemistry. ,vol. 268, pp. 5332- 5338 ,(1993) , 10.1016/S0021-9258(18)53537-7