Ocular Presentations of Amyloidosis

摘要: Amyloidosis is a term used for some clinical disorders that result from deposition of in‐ soluble amyloid fibrils in extraand intracellular spaces leading to many tissue dysfunc‐ tions and disrupt architectures human body. These set with similar pathophysiology, involvement metabolic pathways protein different tissue.[1-3] Amyloid deposits various groups amyloidosis have these common findings: 1. Homogeneous granular, filamentous eosinophilia hematoxylin eosin staining. 2. Metachromasia crystal violet 3. Ultraviolet fluorescence Thioflavin-T staining 4. Orange-red Congo red, which exhibits two additional properties – Bire‐ fringence (ability rotate polarized light by 90°) Dichroism (red green color change under light). proteins can be classified into: a. Immunoglobulin chains (AL) primary systemic amyloidosis. b. A (AA) secondary c. Transthyretine familial d. known as P component (AP ). conditions may or secondary, localized systemic, nonfamilial. Primary amyloi‐ dosis includes so like heart failure, gastrointestinal tract