Comparison of oxygen uptake during bicycle exercise in patients with chronic heart failure and in normal subjects

作者: Alain Cohen Solal , Jean Marc Chabernaud , René Gourgon

DOI: 10.1016/0735-1097(90)90460-7

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摘要: Abstract Prediction of oxygen uptake ( V ˙ O 2 ) during exercise from relations established in normal subjects between and work load watts (W) may be inaccurate patients with chronic heart failure because these could manifest delayed kinetics at final stages exercise. To test the hypothesis that even low levels work, exhibit a lower than do subjects, 77 27 control or disease other underwent bicycle respiratory gas analysis. Work was increased by 10 W/min an initial 20 W. (ml/min per kg) measured every 15 s. The Δ / W ratio significantly reduced only most severely impaired class C-D (8.75 ± 2.14 versus 11.05 0.38, p Even incremental rate protocol, compared sedentary without failure, demonstrate uptake. This observation suggests presence anaerobic metabolism uptake, both; accordingly, indirect estimates requirements derived intensity duration such are overestimated.

参考文章(23)
B J Whipp, Dynamics of pulmonary gas exchange. Circulation. ,vol. 76, ,(1987)
K T Weber, G T Kinasewitz, J S Janicki, A P Fishman, Oxygen utilization and ventilation during exercise in patients with chronic cardiac failure. Circulation. ,vol. 65, pp. 1213- 1223 ,(1982) , 10.1161/01.CIR.65.6.1213
Joseph A. Franciosa, Susan Ziesche, R.N. Mary Wilen, Functional capacity of patients with chronic left ventricular failure The American Journal of Medicine. ,vol. 67, pp. 460- 466 ,(1979) , 10.1016/0002-9343(79)90794-0
J R Wilson, J L Martin, D Schwartz, N Ferraro, Exercise intolerance in patients with chronic heart failure: role of impaired nutritive flow to skeletal muscle. Circulation. ,vol. 69, pp. 1079- 1087 ,(1984) , 10.1161/01.CIR.69.6.1079
James E. Hansen, Darryl Y. Sue, Ami Oren, Karlman Wasserman, Relation of oxygen uptake to work rate in normal men and men with circulatory disorders American Journal of Cardiology. ,vol. 59, pp. 669- 674 ,(1987) , 10.1016/0002-9149(87)91190-8
D P Lipkin, J Perrins, P A Poole-Wilson, Respiratory gas exchange in the assessment of patients with impaired ventricular function. Heart. ,vol. 54, pp. 321- 328 ,(1985) , 10.1136/HRT.54.3.321
D H Wiener, L I Fink, J Maris, R A Jones, B Chance, J R Wilson, Abnormal skeletal muscle bioenergetics during exercise in patients with heart failure: role of reduced muscle blood flow. Circulation. ,vol. 73, pp. 1127- 1136 ,(1986) , 10.1161/01.CIR.73.6.1127
Joseph Hung, Danielle Goldwater, Victor A. Convertino, James H. McKillop, Michael L. Goris, Robert F. DeBusk, Mechanisms for decreased exercise capacity after bed rest in normal middle-aged men The American Journal of Cardiology. ,vol. 51, pp. 344- 348 ,(1983) , 10.1016/S0002-9149(83)80063-0