Recurrence following neurosurgeon-determined gross-total resection of adult supratentorial low-grade glioma: results of a prospective clinical trial: Clinical article
作者： Edward G. Shaw , Brian Berkey , Stephen W. Coons , Dennis Bullard , David Brachman
DOI: 10.3171/JNS/2008/109/11/0835
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摘要: Object In 1998, the Radiation Therapy Oncology Group initiated a Phase II study of observation for adults < 40 years old with cerebral low-grade glioma who underwent neurosurgeon-determined gross-total resection (GTR). Methods Patient eligibility criteria included presence World Health Organization Grade astrocytoma, oligodendroglioma, or mixed oligoastrocytoma confirmed histologically; age 18–39 years; Karnofsky Performance Scale score ≥ 60; Neurologic Function ≤ 3; supratentorial tumor location; GTR; and pre- postoperative MR imaging contrast enhancement available central review by principal investigator. Patients were observed following GTR every 6 months. Prognostic factors analyzed their contribution to patient overall survival, progression-free survival (PFS), recurrence age, sex, score, histological type, enhancement...
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