Changes in circulating VEGF levels in relation to clinical response during chemotherapy for metastatic cancer

摘要: Abnormally high blood levels of vascular endothelial growth factor (VEGF) appear to be associated with a poor prognosis in advanced cancer, probably as consequence its angiogenic and immunosuppressive effects. The prognostic significance changes VEGF secretion during cancer chemotherapy is still unknown. This study aimed investigate the relation between variations therapeutic results malignancies. included 90 metastatic patients, 59 non-small cell lung 31 colorectal carcinoma. Chemotherapy consisted cisplatin plus etoposide for NSCLC camptothecin cancer. (> 2 SD respect values healthy controls) pretreatment were found 38/90 (42%) patients. percentage non-progressive disease response was significantly higher patients normal prior therapy than those elevated (10/32 vs 4/27; p < 0.05). Moreover, level normalization objective tumor or stable progressing (10/18 0/20; 0.001). Finally, among stabilization, one-year survival rate chemotherapy-induced persistently (9/10 3/8; These suggest that may represent useful biomarker predict effect terms solid neoplasms.