Muscarinic antagonists for treating memory loss
作者： Theodros Asberom , Derek B. Lowe , Michael J. Green
DOI:
关键词:
摘要: 1,4 Di-substituted piperidine muscarinic antagonists of formula I ##STR1## or a pharmaceutically acceptable salt, ester, solvate thereof, wherein X is bond, --O--, --SO 0-2 --, --CO--, --C(OR 7 ) 2 --CH --O--CH --CH═CH--, --CH(C 1 --C 6 alkyl)--, --C(C alkyl) --CONR 17 --NR CO--, NR -- SO --; R C 3 cycloalkyl, optionally substituted phenyl pyridyl; H, --CN, --CF , alkyl, cycloalkenyl, alkenyl, --COR 15 --COO(alkyl, aryl, heteroaryl, alkylaryl alkylheteroaryl), alkylaryl, alkylheteroaryl --CON(R 13 ; t-butoxycarbonyl 4-piperidinyl; and 4 5 are as defined in the specification disclosed being useful for treating cognitive disorders such Alzheimer's disease; also pharmaceutical compositions, methods preparation combinations compounds capable enhancing ACh release with ACh'ase inhibitors.
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