Ca2+ signaling regulates ecmB expression, cell differentiation and slug regeneration in Dictyostelium.
作者： Yekaterina Poloz , Danton H. O'Day
DOI: 10.1016/J.DIFF.2012.02.009
关键词:
摘要: Abstract Ca 2+ regulates cell differentiation and morphogenesis in a diversity of organisms dysregulation signal transduction pathways leads to many cellular pathologies. In Dictyostelium induces ecmB expression stalk vitro . Here we have analyzed the pattern intact bisected slugs effect agents that affect levels or antagonize calmodulin (CaM) on this pattern. We shown CaM regulate pstAB/pstB vivo Agents increase intracellular increased and/or pstAB pstB differentiation, while decrease decreased it. isolated slug tips had differential anterior versus posterior zones. number expressing cells region slugs, activity posterior. also demonstrated motility regeneration shape backs backs. To our knowledge, is first study detailing regenerating as well role process expression.
elsevier.com
sci-hub.se 参考文章(81)
P. Schaap, T. Nebl, P. R. Fisher, A slow sustained increase in cytosolic Ca2+ levels mediates stalk gene induction by differentiation inducing factor in Dictyostelium. The EMBO Journal. ,vol. 15, pp. 5177- 5183 ,(1996) , 10.1002/J.1460-2075.1996.TB00902.X
Preeti Chhabra, Ramamurthy Baskar, Priya Mascarenhas, Vidyanand Nanjundiah, A cell type-specific effect of calcium on pattern formation and differentiation in Dictyostelium discoideum The International Journal of Developmental Biology. ,vol. 44, pp. 491- 498 ,(2000) , 10.1387/IJDB.11032184
Peter W. Reed, Henry A. Lardy, A23187: A Divalent Cation Ionophore Journal of Biological Chemistry. ,vol. 247, pp. 6970- 6977 ,(1972) , 10.1016/S0021-9258(19)44681-4
D. Ridgway, J.A. Tuszynski, Y.K. Tam, Reassessing models of hepatic extraction. Journal of Biological Physics. ,vol. 29, pp. 1- 21 ,(2003) , 10.1023/A:1022531403741
Yuzuru Kubohara, Akiko Arai, Naomi Gokan, Kohei Hosaka, Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca(2+) and H(+) concentrations in Dictyostelium discoideum. Development Growth & Differentiation. ,vol. 49, pp. 253- 264 ,(2007) , 10.1111/J.1440-169X.2007.00920.X
Yuzuru Kubohara, Koji Okamoto, Cytoplasmic Ca2+ and H+ concentrations determine cell fate in Dictyostelium discoideum. The FASEB Journal. ,vol. 8, pp. 869- 874 ,(1994) , 10.1096/FASEBJ.8.11.8070636
J.G. Williams, K.A. Jermyn, An analysis of culmination in Dictyostelium using prestalk and stalk-specific cell autonomous markers. Development. ,vol. 111, pp. 779- 787 ,(1991) , 10.1242/DEV.111.3.779
Dirk Dormann, Cornelis J. Weijer, Propagating chemoattractant waves coordinate periodic cell movement in Dictyostelium slugs. Development. ,vol. 128, pp. 4535- 4543 ,(2001) , 10.1242/DEV.128.22.4535
Nicholas C. Spitzer, Nathan J. Lautermilch, Raymond D. Smith, Timothy M. Gomez, Coding of neuronal differentiation by calcium transients BioEssays. ,vol. 22, pp. 811- 817 ,(2000) , 10.1002/1521-1878(200009)22:9<811::AID-BIES6>3.0.CO;2-G
H. Hidaka, Y. Sasaki, T. Tanaka, T. Endo, S. Ohno, Y. Fujii, T. Nagata, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 4354- 4357 ,(1981) , 10.1073/PNAS.78.7.4354