Polarization of Tumor Infiltrating Leukocytes from Innate Immunity and their role in the Pro-angiogenic Phenotype in NSCLC

摘要: Non-small cell lung cancer (NSCLC), the most frequent (80%), can be phenotypically classified into two main subtypes: squamous carcinoma (SCC) and adenocarcinoma (ADC). While SCC has relatively rapid doubling times from onset, ADC longer initially that become reduced during tumor progression, suggesting a key role for microenvironment. During complex dynamic interplay occurs between proliferating cells stromal, endothelial immune tumor-conditioned host within microenvironment (TUMIC). Several factors TUMIC, such as hypoxia, cytokines soluble factors, appear to blunt anti-tumor response polarize towards pro-tumor phenotype. Phenotypically functionally altered found in patients include macrophages, neutrophils, myeloid, dendritic, even NK cells. We studied infiltrating (TINK) associated (TANK) NSCLC. NSCLC TINKs TANKs show similarities decidual cells, being polarized toward tissue builders, rather than killers, producing pro-angiogenic cytokines. The provide stromal support neovascularization required expansion progression feed-forward mechanism, leading progression. Further, systemic alterations of are also present patients. precise knowledge these TUMIC crucial diagnosis, targeted therapeutic intervention, well prevention, cancer.