Biomechanical Factors Analysis in Aneurysm

摘要: All the cells in body need to receive food (nutrients, metabolic products) and dispose of waste products. The responsible system for that is cardiovascular system. It supply through arteries return products veins all living human body. This task reached by a circulating fluid, blood. central location which lines originate from small, very pump, heart. heart keeps fluid circulation. In heart, there are two pumps, propelling blood into pulmonary systemic circulation combined single muscular organ synchronously beat. Any disruption flow causes supply. Life not possible without blood, but truth life must pump at times, it does contracting relaxing rhythmic pattern, approximately once every second, more than 86 thousand times day, about 2 billion lifetime 75 years, nonstop (Zamir, 2005). ejected follows direction arterial tree. Along tree, successively decrease size, increase number, undergo structural changes, finish arterioles as little 10 m diameter. structure artery quite complex. main components vessel wall endothelium, smooth muscle cells, elastic tissue, collagen, connective tissue. targets diseases such atherosclerosis or aneurysms each year claims lives scores people worldwide. disease may be triggered aggravated mechanical stimuli, stress stretch resulting pressure, shear (Wernig Xu, 2002). Arteries can also adapt long-term physiological conditions thinning thickening layer, altering relative composition organization various assemblies proteins process generally know remodelling. Bessa et al. (2011) showed occurs remodelling tail bed normotensive hypertensive rats. As shown Figure 1, internal diameter proximal portion did differ between Wistar rats spontaneously (SHR), whereas intermediate distal portions SHR tails were significant smaller those