Decreased lymphocytes and increased risk for infection are common in endogenous pediatric Cushing syndrome

摘要: BackgroundHypercortisolemia results in changes of the immune system and elevated infection risk, but data on WBC pediatric Cushing syndrome (CS) are not known. We describe lineages endogenous hypercortisolemia, their associations with markers disease severity, presence infections.MethodsWe identified 197 children CS. Clinical biochemical were recorded. Sixty-six similar age gender, normocortisolemia served as controls.ResultsThe absolute lymphocyte count CS patients was significantly lower than that controls, while total neutrophil counts higher. These correlated several severity improved after resolution hypercortisolemia. Infections 35 (17.8%), to serum morning cortisol, midnight urinary free cortisol levels, well decrease count.ConclusionsChildren have abnormal counts, which correlate CS, normalize cure. common this population; clinicians should be aware complication low threshold diagnosis treating infections