Human Dendritic Cells: Potent Antigen-Presenting Cells at the Crossroads of Innate and Adaptive Immunity
作者： Marco Rossi , James W. Young
DOI: 10.4049/JIMMUNOL.175.3.1373
关键词:
摘要: Dendritic cells (DCs) are specialized, bone marrow-derived leukocytes that critical to the development of immunity. Investigators have emphasized role DCs in initiating adaptive or acquired MHC-restricted, Ag-specific T cell responses. More recent evidence supports important roles for onset innate immunity and peripheral tolerance. Progress generation from defined hemopoietic precursors vitro has revealed heterogeneity these APCs their attendant divisions labor. This review will address developments an attempt integrate activities different coordinating
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