The effects of omega-3 polyunsaturated fatty acids on blood pressure: a methodologic analysis of the evidence.
作者： K Radack , C Deck
DOI: 10.1080/07315724.1989.10720312
关键词:
摘要: The potentially beneficial blood pressure (BP)-lowering effects of marine omega-3 polyunsaturated fatty acids (omega-3-PUFAs) remain controversial. objective this qualitative and quantitative (meta-analysis) analysis was to evaluate the results all available randomized controlled trials that studied effect omega-3-PUFAs on BP response. A comprehensive search English literature from 1970 1988 disclosed only six investigations out 22 published reports. Four these were evaluable therefore eligible for analysis. Of these, one evaluated hypertensive subjects. In two trials, there statistically significant reductions in BP; reporting an investigation subjects showed greatest reduction. Using established methodologic criteria, quality each report by independent observers. Following appraisal, outcomes reanalyzed pooled using a meta-analysis. There no difference between omega-3-PUFA groups control groups, possibly because failure include but trial. Despite positive studies, little scientifically valid evidence is demonstrate BP-lowering omega-3-PUFAs. Areas needing more attention future research are identified methods improve study designs suggested.
sci-hub.se 参考文章(42)
J Z Mortensen, E B Schmidt, A H Nielsen, J Dyerberg, The effect of N-6 and N-3 polyunsaturated fatty acids on hemostasis, blood lipids and blood pressure. Thrombosis and Haemostasis. ,vol. 50, pp. 543- 546 ,(1983) , 10.1055/S-0038-1665251
KAJ ANKER JØRGENSEN, ARNE HØJ NIELSEN, JØRN DYERBERG, Hemostatic factors and renin in Greenland Eskimos on a high eicosapentaenoic acid intake. Results of the Fifth UmanaK Expedition. Acta Medica Scandinavica. ,vol. 219, pp. 473- 479 ,(2009) , 10.1111/J.0954-6820.1986.TB03342.X
S Rogers, Kim S. James, Barbara K Butland, M.D Etherington, J.R O'Brien, J.G Jones, Effects of a fish oil supplement on serum lipids, blood pressure, bleeding time, haemostatic and rheological variables. A double blind randomised controlled trial in healthy volunteers Atherosclerosis. ,vol. 63, pp. 137- 143 ,(1987) , 10.1016/0021-9150(87)90113-4
R von Houwelingen, A Nordøy, E van der Beek, U Houtsmuller, M de Metz, G Hornstra, Effect of a moderate fish intake on blood pressure, bleeding time, hematology, and clinical chemistry in healthy males. The American Journal of Clinical Nutrition. ,vol. 46, pp. 424- 436 ,(1987) , 10.1093/AJCN/46.3.424
P M Herold, J E Kinsella, Fish oil consumption and decreased risk of cardiovascular disease: a comparison of findings from animal and human feeding trials. The American Journal of Clinical Nutrition. ,vol. 43, pp. 566- 598 ,(1986) , 10.1093/AJCN/43.4.566
F M Sacks, M J Stampfer, A Munoz, K McManus, M Canessa, E H Kass, Effect of linoleic and oleic acids on blood pressure, blood viscosity, and erythrocyte cation transport. Journal of The American College of Nutrition. ,vol. 6, pp. 179- 185 ,(1987) , 10.1080/07315724.1987.10720179
Peter Singer, Ingrid Berger, Kortina Lück, Christa Taube, Erna Naumann, Wolfgang Gödicke, Long-term effect of mackerel diet on blood pressure, serum lipids and thromboxane formation in patients with mild essential hypertension. Atherosclerosis. ,vol. 62, pp. 259- 265 ,(1986) , 10.1016/0021-9150(86)90100-0
Peter Singer, Ingrid Berger, Manfred Wirth, Wolfgang Gödicke, Waltraud Jaeger, Siegfried Voigt, Slow desaturation and elongation of linoleic and α-linolenic acids as a rationale of eicosapentaenoic acid-rich diet to lower blood pressure and serum lipids in normal, hypertensive and hyperlipemic subjects Prostaglandins, Leukotrienes and Medicine. ,vol. 24, pp. 173- 193 ,(1986) , 10.1016/0262-1746(86)90125-3
Tomohito Hamazaki, Ryoichi Nakazawa, Sumio Tateno, Hideo Shishido, Kazuo Isoda, Yoshihiro Hattori, Toyohiko Yoshida, Takao Fujita, Saburo Yano, Akira Kumagai, Effects of fish oil rich in eicosapentaenoic acid on serum lipid in hyperlipidemic hemodialysis patients. Kidney International. ,vol. 26, pp. 81- 84 ,(1984) , 10.1038/KI.1984.137
Stuart J. Pocock, Michael D. Hughes, Robert J. Lee, Statistical Problems in the Reporting of Clinical Trials New England Journal of Medicine. ,vol. 317, pp. 426- 432 ,(1987) , 10.1056/NEJM198708133170706