Effect of linoleic and oleic acids on blood pressure, blood viscosity, and erythrocyte cation transport.
作者： F M Sacks , M J Stampfer , A Munoz , K McManus , M Canessa
DOI: 10.1080/07315724.1987.10720179
关键词:
摘要: It has been proposed that dietary linoleic acid lowers blood pressure (BP) by being converted to arachidonic and prostanoids of the two-ene series. We tested effects on plasma acid, pressure, viscosity, RBC cation transport. Oleic major monounsaturated fat which is not a prostanoid precursor, was used as control. Seventeen adults consumed 23 g/d or oleic provided genetic variants safflower seed, each for 4 weeks in double-blind crossover design. Linoleic acids were enriched significantly cholesteryl esters, phospholipids triglycerides during respective periods supplementation but there no increase arachidonate. Mean BP 116.1/76.8 ingestion 113.6/74.6 (p = 0.09 systolic, p 0.12 diastolic). The power study over 75% detecting significant less than 0.05) effect mm Hg systolic diastolic BP. Whole Li/Na countertransport, Na/K cotransport, Na pump systems (Vmax) unchanged protocol. Therefore, variations are unlikely have several membrane-dependent erythrocyte functions related hypertension.
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sci-hub.se 参考文章(47)
Murray Epstein, Meyer Lifschitz, Kenneth Rappaport, Augmentation of prostaglandin production by linoleic acid in man. Clinical Science. ,vol. 63, pp. 565- 571 ,(1982) , 10.1042/CS0630565
Kevin D. Croft, Lawrence J. Beilin, Robert Vandongen, Elaine Mathews, Dietary modification of fatty acid and prostaglandin synthesis in the rat: Effect of variations in the level of dietary fat Biochimica et Biophysica Acta. ,vol. 795, pp. 196- 207 ,(1984) , 10.1016/0005-2760(84)90066-3
W C Willett, M J Stampfer, B A Underwood, F E Speizer, B Rosner, C H Hennekens, Validation of a dietary questionnaire with plasma carotenoid and alpha-tocopherol levels. The American Journal of Clinical Nutrition. ,vol. 38, pp. 631- 639 ,(1983) , 10.1093/AJCN/38.4.631
Bernard Rosner, Percentage Points for a Generalized ESD Many-Outlier Procedure Technometrics. ,vol. 25, pp. 165- 172 ,(1983) , 10.1080/00401706.1983.10487848
Richard Cooper, Kenneth Miller, Maurizio Trevisan, Christopher Sempos, Emmanuel Larbi, Hirotsugu Ueshima, Daniel Le Grady, David Ostrow, Jeremiah Stamler, Anda Spalvins, Mitzy Canessa, Family History of Hypertension and Red Cell Cation Transport in High School Students Journal of Hypertension. ,vol. 1, pp. 145- 152 ,(1983) , 10.1097/00004872-198308000-00006
J.J. Myher, A. Kuksis, J. Shepherd, C.J. Packard, J.D. Morrisett, O.D. Taunton, A.M. Gotto, Effect of saturated and unsaturated fat diets on molecular species of phosphatidylcholine and sphingomyelin of human plasma lipoproteins Biochimica et Biophysica Acta. ,vol. 666, pp. 110- 119 ,(1981) , 10.1016/0005-2760(81)90096-5
R Lorenz, U Spengler, S Fischer, J Duhm, P C Weber, Platelet function, thromboxane formation and blood pressure control during supplementation of the Western diet with cod liver oil. Circulation. ,vol. 67, pp. 504- 511 ,(1983) , 10.1161/01.CIR.67.3.504
Peter Singer, Waltraud Jaeger, Siegfried Voigt, Helmut Thiel, Defective desaturation and elongation of N-6 and N-3 fatty acids in hypertensive patients Prostaglandins, Leukotrienes and Medicine. ,vol. 15, pp. 159- 165 ,(1984) , 10.1016/0262-1746(84)90173-2
Jacqueline M Lillington, DJH Trafford, HLJ Makin, None, A rapid and simple method for the esterification of fatty acids and steroid carboxylic acids prior to gas-liquid chromatography. Clinica Chimica Acta. ,vol. 111, pp. 91- 98 ,(1981) , 10.1016/0009-8981(81)90425-3
Ian L. Rouse, Bruce K. Armstrong, Lawrence J. Beilin, The Relationship of Blood Pressure to Diet and Lifestyle in Two Religious Populations Journal of Hypertension. ,vol. 1, pp. 65???72- 70 ,(1983) , 10.1097/00004872-198306000-00011