Augmentation of prostaglandin production by linoleic acid in man.
作者： Murray Epstein , Meyer Lifschitz , Kenneth Rappaport
DOI: 10.1042/CS0630565
关键词:
摘要: 1. Since several lines of evidence have suggested that a diminution endogenous prostaglandins (PG) may participate in the pathogenesis variety disease states, it would be advantageous to develop therapeutic approaches augment prostaglandin synthesis. linoleic acid is readily converted arachidonic acid, we assessed effects administration on immunoassayable PGE and 6-oxo-PGF1 alpha excretion as indices PGE2 PGI2 production. 2. Six normal subjects were studied twice: during seated control study an 8 h infusion 10% emulsion safflower oil (Liposyn) containing approx. 77% dose 1.5 g/kg body weight. 3. Liposyn induced profound increase excretion. 4. Simultaneously, increased modestly. 5. The current raises possibility might constitute new approach managing disorders characterized by impairment ability
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