Age-related changes in expression of hippocalcin and NVP2 in rat brain.
作者： Yoshitaka Furuta , Masaaki Kobayashi , Tamotsu Masaki , Ken Takamatsu
关键词:
摘要: Expression of hippocalcin and neural visinin-like calcium-binding protein 2 (NVP2) in aging rat brain was investigated by immunoblot immunohistochemical analyses. In 3-month old rats, NVP2 were present at high concentrations hippocampal cerebral pyramidal cells dentate granule cells, with levels being five to ten times higher than levels. Hippocalcin hippocampus cortex decreased approximately 20% 24 months. While the number hippocalcin-positive CA3, gyrus preserved, staining intensity decreased. contrast, CA1 maintained. 30% cortex, NVP2-positive through CA3 gyrus, cell numbers but summary, loss may be associated age-related impairment postsynaptic functions.
springer.com
sci-hub.se 参考文章(51)
Neelima Chauhan, George Siegel, Age-Dependent Organotypic Expression of Microtubule-Associated Proteins (MAP1, MAP2, and MAP5) in Rat Brain Neurochemical Research. ,vol. 22, pp. 713- 719 ,(1997) , 10.1023/A:1027306227402
M. Kobayashi, K. Takamatsu, S. Saitoh, T. Noguchi, Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties Journal of Biological Chemistry. ,vol. 268, pp. 18898- 18904 ,(1993) , 10.1016/S0021-9258(17)46711-1
Shigeharu Saitoh, Ken Takamatsu, Masaaki Kobayashi, Tetsuya Noguchi, Immunohistochemical localization of neural visinin-like Ca2+-binding protein 2 in adult rat brain Neuroscience Letters. ,vol. 171, pp. 155- 158 ,(1994) , 10.1016/0304-3940(94)90628-9
Mitsuhiko Ikura, Calcium binding and conformational response in EF-hand proteins Trends in Biochemical Sciences. ,vol. 21, pp. 14- 17 ,(1996) , 10.1016/S0968-0004(06)80021-6
Neelam Narang, In situ determination of M1 and M2 muscarinic receptor binding sites and mRNAs in young and old rat brains Mechanisms of Ageing and Development. ,vol. 78, pp. 221- 239 ,(1995) , 10.1016/0047-6374(94)01539-X
Beat W. Schäfer, Claus W. Heizmann, The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends in Biochemical Sciences. ,vol. 21, pp. 134- 140 ,(1996) , 10.1016/S0968-0004(96)80167-8
C.A Barnes, G Rao, J Shen, Age-Related Decrease in the N-Methyl-d-AspartateR-Mediated Excitatory Postsynaptic Potential in Hippocampal Region CA1 Neurobiology of Aging. ,vol. 18, pp. 445- 452 ,(1997) , 10.1016/S0197-4580(97)00044-4
C.A. Barnes, Normal aging: regionally specific changes in hippocampal synaptic transmission Trends in Neurosciences. ,vol. 17, pp. 13- 18 ,(1994) , 10.1016/0166-2236(94)90029-9
Karl-Heinz Braunewell, Christina Spilker, Thomas Behnisch, Eckart D. Gundelfinger, The Neuronal Calcium‐Sensor Protein VILIP Modulates Cyclic AMP Accumulation in Stably Transfected C6 Glioma Cells: Amino‐Terminal Myristoylation Determines Functional Activity Journal of Neurochemistry. ,vol. 68, pp. 2129- 2139 ,(2002) , 10.1046/J.1471-4159.1997.68052129.X
Yuri Geinisman, Leyla de Toledo-Morrell, Frank Morrell, Inna S. Persina, Marvin Rossi, Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique. Hippocampus. ,vol. 2, pp. 437- 444 ,(1992) , 10.1002/HIPO.450020411