In situ determination of M1 and M2 muscarinic receptor binding sites and mRNAs in young and old rat brains
作者： Neelam Narang
DOI: 10.1016/0047-6374(94)01539-X
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摘要: Abstract Changes in M1, M2 receptor binding and mRNA aged (25–26 months) rat brains were examined to determine whether decreases receptors are due declines expression of corresponding levels. With aging, the muscarinic sites m2 significantly decreased medial septum diagonal band Broca. In addition, was also reduced basal ganglia, CA3 field hippocampus, deeper layers cortex, central nuclei amygdala, thalamic nuclei. However, M1 superficial hippocampus lateral amygdala. There no change m1 between any brain region young old rats. These studies suggest reduction subtype during transcriptional process, alterations subtypes translational or post-transcriptional periods.
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