Evaluation of muscarinic M2 receptor sites in basal forebrain and brainstem cholinergic systems of behaviorally characterized young and aged long-evans rats
作者： T.M Gill , M Gallagher
DOI: 10.1016/S0197-4580(98)00048-7
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摘要: Abstract Aged (23–25-month-old) male Long-Evans rats were assessed for deficits in spatial cognition relative to young (4–6-month-old) rats. An vitro autoradiography study was then conducted muscarinic M2 sites using [3H]AF-DX 384 assess binding basal forebrain and brainstem areas where cholinergic neurons are localized. The analysis of included the medial septal/diagonal band region that provides innervation hippocampus; laterodorsal tegmental nucleus pedunculopontine analyzed brainstem. A significant age-related reduction found both Only forebrain, however, correlated with learning impairment. Although systems each vulnerable normal aging, contributions behavioral effects aging may be distinctive two systems.
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