Proximity to vector breeding site and risk of Plasmodium vivax infection: a prospective cohort study in rural Ethiopia.

摘要: Despite falling incidence and mortality since the turn of century, malaria remains an important global health challenge. In future fight against malaria, greater emphasis will have to be placed on understanding addressing caused by Plasmodium vivax parasite. Unfortunately, due years neglect underfunding, there are currently many gaps in knowledge P. malaria. The aims present study were explore association between distance vector breeding site infection rural Ethiopia, and, secondarily, test whether this varies with age. A prospective, cohort all residents Chano Mille Kebele southern Ethiopia from April 2009 March 2011 (n = 8121). Weekly household follow up visits included screening for febrile cases (active surveillance). Participants also asked contact local centre if they experienced subjective fever (passive was confirmed using microscopy two independent readers. Information collected demographics characteristics including GPS-determined site. Data analysed Cox regression modelling. Overall rate 12.3/1000 person-years (95% CI 10.5–14.5). Mean 2449 m (range 1646–3717 m). Fully adjusted results showed very strong evidence proximity infection: ratio = 3.47 2.15–5.60; P   2700 m; n = 2460). There no that age effect modifier association. Results is positively associated constant across groups. findings might influence how net-distribution indoor residual spraying campaigns planned, help guide strategies water resource development highlighting potential effects man-made dams near human habitats, add current educational information given people living close sites.