Inhibin B and anti-Mullerian hormone: markers of ovarian response in IVF/ICSI patients?

摘要: Objective  The objective of this study was to investigate whether follicle stimulating hormone (FSH), anti-Mullerian (AMH) and inhibin B could be useful in predicting the ovarian response gonadotrophin stimulation assisted reproduction patients who are considered poor responders. Design  Prospective study. Setting  Fertility unit. Sample  Blood samples were collected on day five or six early follicular phase an untreated menstrual cycle. Samples from 69 patients. Methods  Serum assayed for FSH, AMH using commercial immunoassay kits. Main outcome measures  Response number eggs collected. Results  Among patients, 52 completed IVF cycle 17 had cancel because stimulation. Mean FSH levels significantly higher (P < 0.05) cancelled group (10.69 ± 2.27 mIU/mL) compared with cycle-completed (7.89 0.78 mIU/mL). lower 0.01) (0.175 0.04 ng/mL) (1.13 0.2 ng/mL). 0.001) (70 12.79 pg/mL) (126.9 8.8 pg/mL). Predictive statistics show that is best single marker combination modestly better than marker. Linear regression analysis shows although (r= 0.25, P 0.35, have a significant linear association collected, has greatest 0.69, among parameters measured. Conclusion  In particular combined markers improved prediction.