Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.
作者： Mikko Niemi , Pertti J. Neuvonen , Ute Hofmann , Janne T. Backman , Matthias Schwab
DOI: 10.1097/01213011-200505000-00005
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摘要: ObjectiveThe aim was to investigate whether polymorphisms in the SLCO1B1 gene, encoding hepatic uptake transporter OATP1B1, influence short-term effects of pravastatin on cholesterol synthesis.MethodsWe determined plasma concentrations lathosterol and up 12 h after intake o
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sci-hub.se 参考文章(39)
Jonathan A. Tobert, Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nature Reviews Drug Discovery. ,vol. 2, pp. 517- 526 ,(2003) , 10.1038/NRD1112
Tomomi Hatanaka, Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events. Clinical Pharmacokinectics. ,vol. 39, pp. 397- 412 ,(2000) , 10.2165/00003088-200039060-00002
Carl Kyrklund, Janne T. Backman, Mikko Neuvonen, Pertti J. Neuvonen, Effect of rifampicin on pravastatin pharmacokinetics in healthy subjects British Journal of Clinical Pharmacology. ,vol. 57, pp. 181- 187 ,(2003) , 10.1046/J.1365-2125.2003.01972.X
Jörg König, Yunhai Cui, Anne T. Nies, Dietrich Keppler, A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 278, ,(2000) , 10.1152/AJPGI.2000.278.1.G156
I Björkhem, T Miettinen, E Reihnér, S Ewerth, B Angelin, K Einarsson, Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver Journal of Lipid Research. ,vol. 28, pp. 1137- 1143 ,(1987) , 10.1016/S0022-2275(20)38603-X
H J Kempen, J F Glatz, J A Gevers Leuven, H A van der Voort, M B Katan, Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. Journal of Lipid Research. ,vol. 29, pp. 1149- 1155 ,(1988) , 10.1016/S0022-2275(20)38456-X
Takashi Nozawa, Miki Nakajima, Ikumi Tamai, Kumiko Noda, Jun-ichi Nezu, Yoshimichi Sai, Akira Tsuji, Tsuyoshi Yokoi, Genetic Polymorphisms of Human Organic Anion Transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): Allele Frequencies in the Japanese Population and Functional Analysis Journal of Pharmacology and Experimental Therapeutics. ,vol. 302, pp. 804- 813 ,(2002) , 10.1124/JPET.302.2.804
Pfohl, Naoumova, Kim, Thompson, Use of cholesterol precursors to assess changes in cholesterol synthesis under non-steady-state conditions. European Journal of Clinical Investigation. ,vol. 28, pp. 491- 496 ,(1998) , 10.1046/J.1365-2362.1998.00321.X
Tatu A. Miettinen, Helena Gylling, Nina Lindbohm, Tatu E. Miettinen, Radhakrishnan A. Rajaratnam, Heikki Relas, Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins Journal of Laboratory and Clinical Medicine. ,vol. 141, pp. 131- 137 ,(2003) , 10.1067/MLC.2003.9
Jessica Mwinyi, Andreas Johne, Steffen Bauer, Ivar Roots, Thomas Gerloff, Evidence for Inverse Effects of OATP-C (SLC21A6) *5 and *1b Haplotypes on Pravastatin Kinetics Clinical Pharmacology & Therapeutics. ,vol. 75, pp. 415- 421 ,(2004) , 10.1016/J.CLPT.2003.12.016