Methods and means for diagnosing and treatment of osteoarthritis
作者： Ingrid Meulenbelt , Eline Petronella Slagboom
DOI:
关键词:
摘要: The current invention provides methods for determining the risk of a subject developing familial generalized osteoarthritis with early or late onset, comprising step presence genetic marker indicative polymorphism affecting function expression gene located on at least one human chromosome bands 2q33.2 to 2q34 and 14q24.3 14q32.12 in genome subject. also pertains sequences polymorphisms therein that may be development
lens.org 参考文章(10)
John Loughlin, Andrew Carr, Bryan Sykes, Susceptibility locus for osteoarthritis ,(2000)
Stacey Bolk, George Q. Daley, Jeanette J. McCarthy, James S. Ireland, Eric S. Lander, Michele Cargill, Single nucleotide polymorphisms in genes ,(2000)
G D Wright, A E Hughes, M Regan, M Doherty, Association of two loci on chromosome 2q with nodal osteoarthritis. Annals of the Rheumatic Diseases. ,vol. 55, pp. 317- 319 ,(1996) , 10.1136/ARD.55.5.317
Hongwei Zhang, Wayne E. Marshall, Choong-Chin Liew, Compositions and methods relating to osteoarthritis ,(2002)
J Loughlin, Z Mustafa, A Smith, C Irven, AJ Carr, K Clipsham, J Chitnavis, VA Bloomfield, M McCartney, O Cox, JS Sinsheimer, B Sykes, KE Chapman, Linkage analysis of chromosome 2q in osteoarthritis. Rheumatology. ,vol. 39, pp. 377- 381 ,(2000) , 10.1093/RHEUMATOLOGY/39.4.377
Ferenc L. Boldog, Ramesh Kekuda, Richard A. Shimkets, Shlomit R. Edinger, Karen Ellerman, Kimberly A. Spytek, Meera Patturajan, John P. Ii Alsobrook, Bryan D. Zerhusen, Valerie L. Gerlach, Linda Gorman, Corine A.M. Vernet, Li Li, Glennda Smithson, Mei Zhong, Charles E. Miller, Daniel K. Rieger, Xiaojia Guo, David W. Anderson, Catherine E. Burgess, Edward Z. Voss, Martin D. Leach, Weizhen Ji, Raymond J. Taupier, Elina Catterton, Mark E. Rothenberg, Therapeutic polypeptides, nucleic acids encoding same, and methods of use ,(2002)
Hideyuki Mototani, Akihiko Mabuchi, Susumu Saito, Mikihiro Fujioka, Aritoshi Iida, Yoshio Takatori, Akihiro Kotani, Toshikazu Kubo, Kozo Nakamura, Akihiro Sekine, Yoshinori Murakami, Tatsuhiko Tsunoda, Kohei Notoya, Yusuke Nakamura, Shiro Ikegawa, A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese Human Molecular Genetics. ,vol. 14, pp. 1009- 1017 ,(2005) , 10.1093/HMG/DDI093
Gregory Pahel, Kerry Quinn, Compositions and methods for treatment of osteoarthritis ,(2003)
Masakazu Inazuka, Tatsuya Watanabe, Preventives/remedies for bone and joint diseases ,(2003)
Gidrol Xavier, Chiocchia Gilles, Marion Sandrine, Breban Maxime, Microarrays allowing molecular profiling of rheumatoid arthritis comparatively to osteoarthritis andtheir use ,(2004)