Leukemia induction in C3H mice following their inoculation with normal AKR lymphoid cells.

摘要: Newborn C3H mice were injected with viable or in vitro X-irradiated cell suspensions from lymph node and spleen mixtures obtained healthy AKR donors aged 12 to 18 months. Of the group normal intact cells, 30% developed a lymphocytic leukemia, whereas none of recipients irradiated cells did so. Genetic analysis showed that leukemias appearing originated de novo recipient animals apparently as result their inoculation immunocompetent lymphoid cells. The results by using this model leukemia induction are discussed on basis participation graft-versus-host reaction process.