Sustained virological response to interferon reduces cirrhosis in chronic hepatitis C: a 1386‐patient study from Taiwan
作者： J.-F. HUANG , M.-L. YU , C.-M. LEE , C.-Y. DAI , N.-J. HOU
DOI: 10.1111/J.1365-2036.2007.03297.X
关键词:
摘要: Summary Background The long-term benefits of interferon-based therapy on preventing cirrhosis at non-cirrhotic stage in chronic hepatitis C patients are not fully clarified. Aim To evaluate the effectiveness regarding to prevention patients. Methods A total 1386 biopsy-proven, (892 received and 494 untreated) were enrolled. Results Fifty-six untreated 51 treated (24 sustained virologic responders 27 non-responders) developed during a mean follow-up period 5.0 (1–16) 5.1 (1–15.3) years, respectively. annual incidences groups 2.26 1.11% (non-responders: 1.99%, responders: 0.74%), 15-year cumulative incidence was significantly lower (9.9%) than (39.8%, P = 0.0008, log-rank test). 14.5-year (4.8%) compared with non-responders (21.6%, P = 0.0007) (36.6%, P < 0.0001). difference significant between controls. Cox proportional hazards regression showed younger age independent negative factors for development. Conclusion response secondary IFN-based could reduce development patients.
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