Studies on B-cell memory. III. T-dependent aspect of B memory generation in mice immunized with T-independent type-2(TI-2) antigen.

摘要: The time course of B-cell memory development to a dinitrophenyl (DNP) T-independent type-2 (TI-2) antigen was investigated by adoptive cell transfer. Strong IgM and IgG developed in BALB/c mice after immunization with DNP-dextran, be recalled challenge either T-dependent (TD) or TI-2 antigen. However, only weak very feeble were detected athymic nude receiving the same as euthymic mice. Once established under probable T influence, its recall seemed independent help did not require sharing carriers between priming antigens. following may concluded. (i) Long-term is induced presence functional cells. (ii) class switch from B pool driven effectively probably cell-dependent.