Genomic Biomarkers in Human Population Studies
作者： Jacqueline S. Danik , Nina P. Paynter , Paul M. Ridker
DOI: 10.1016/B978-0-12-382227-7.00021-5
关键词:
摘要: The pace of discovery genetic determinants complex disease has accelerated with the availability gene chips that allow scientists to conduct large-scale genome-wide association studies. In this chapter, we address in three parts use single nucleotide polymorphisms (SNPs) as biomarkers for population-based research. first section, studies (GWAS) discover intermediate phenotypes interest process is examined. second concept using individual SNPs and multi-loci SNP panels potential predictors incident disease. Finally, review genomic evolving field pharmacogenomics. Throughout examples from cardiovascular medicine a template discussing utility limitations biomarker data population
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