Relation of polymorphism within the C-reactive protein gene and plasma CRP levels

摘要: We sought to investigate whether genetic variability within the CRP gene affects levels. C-reactive protein (CRP), an acute-phase reactant in inflammation, is important predictor for cardiovascular disease. The determinants of plasma level remain unknown. assessed genotypes two common polymorphisms gene, exonic 1059G > C and intronic T A base substitution, among 2397 participants a community-based study; 1334 had no prior history, while 1063 history. Univariable multivariable-adjusted analyses were performed examine association with levels, modeling different modes inheritance. significantly associated baseline levels univariable analysis (1059G C: GG versus GC or CC genotypes, median 0.22 0.15 mg/L, P A: TT AT AA 0.19 0.23 0.24 = 0.003). This relationship persisted after adjusting age, sex, body mass index, ethnicity, hypertension, smoking, diabetes, hyperlipidemia, aspirin use. Furthermore, these effects present subgroup limited those without prevalent coronary disease, when Caucasians only. data provide evidence component independently traditional risk factors Whether markers can add information yielded by high sensitivity (hsCRP) assessing needs further evaluation.